Recombinant STING/TMEM173 antibody (C-Term)

Catalog No. ABIN7795818

The Rabbit Monoclonal anti-STING/TMEM173 antibody has been validated for WB, IHC, IP and ICC. It is suitable to detect STING/TMEM173 in samples from Human.

Quick Overview for Recombinant STING/TMEM173 antibody (C-Term) (ABIN7795818)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: BLR373N

Product Details anti-STING/TMEM173 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-STING/TMEM173 Recombinant Monoclonal Antibody [BLR373N]

Purification: Purified

Immunogen: between 329 and 379 (C-term)

Isotype: IgG

Application Details

Application Notes: IHC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.,WB,11000,ICC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.,IP,12 μL/mg lysate

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 500 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: STING/TMEM173

Background: STING/TMEM173 is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86WV6].

Gene ID: 340061

UniProt: Q86WV6

Pathways: Activation of Innate immune Response